P lab

Molecular Recognition

Linus Pauling once remarked that “the secret of life is molecular recognition; the ability of one molecule to ‘recognize’ another through weak bonding interactions.” Understanding the high-specificity, high-affinity recognition of ligands by proteins remains a fundamental challenge in biochemistry. We are currently studying the ligand binding domains of bacterial chemoreceptor proteins. We are using a variety of biochemical and structural approaches to explore the functional and structural diversity of these proteins. This research will provide detailed insights into molecular recognition by chemoreceptors. In turn, we hope that these insights will help to improve the design of protein-ligand interactions. We are also exploring the use of our designed ligand binding proteins as biosensors and as components of diagnostic devices.